Synthesis of Water Soluble Spin Labeled Glucose Derivatives as Potential NMR Contrast Enhancing Agents
نویسندگان
چکیده
Synthetic m ethodologies for the preparation of nitroxyl labeled derivatives of D-( + )-glucose, a-D -( + )-m ethylglycoside, 2-am ino-2-deoxy-D-( + )-glucose, and D-( + )-glucuronic acid are pre sented. The spin labels in these compounds are attached variably at the 1, 2, 3, and 6 positions of the glucose framework. These new com pounds, being water soluble and producing marked en hancement of spin-lattice (T ,) and spin-spin (T2) proton relaxation in deionized water and human plasma have potential utility as contrast altering pharmaceuticals for magnetic resonance imaging and as spin probes in biomolecular research. These spin labeled carbohydrates may demonstrate in vivo biodistribution characteristics reflecting tissue-specific differences in glucose metabolism.
منابع مشابه
Spin Labeled Bovine Serum Albumin, Spin Labeled Bovine Serum Albumin Chelating Agents and Their Gadolinium Complexes. Potential Contrast Enhancing Agents for Magnetic Resonance Imaging
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